Abstract
Summary The activity of lactate dehydrogenase decreased significantly in fast-twitch red (58%) and fast-twitch white (22%) muscle fibers in rats subjected to a 12-week running program. These decreases were accompanied by a reduction in M subunit; the total content of H subunit was unchanged. The largest reduction in M subunit was found in fast-twitch red fibers (8.5%) with a smaller decrease in fast-twitch white (1.4%). Lactate dehydrogenase activity and isozyme composition in slow-twitch red fibers remained unchanged as a result of the exercise program.
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