Alterations in serum enzymes and isoenzymes in various species induced by epinephrine

Abstract

1. 1. The administration of epinephrine to rats, rabbits, guinea pigs and dogs leads to an elevation of several serum enzyme levels. 2. 2. Serum lactic dehydrogenase isoenzyme patterns and histological examination indicate that several tissues may contribute to this increase, but that there is a relatively greater contribution from cardiac tissue and/or erythrocytes. 3. 3. Adrenergic blocking agents prevent the serum enzyme alterations, the tissue changes and the abnormal isoenzyme patterns induced by epinephrine. 4. 4. A likely cause of the serum elevations is an increase in cellular permeability.