Abstract
Rats were chronically infused with phencyclidine (PCP, 13.3 mg PCP·HCl/kg/day) or saline, s.c., for 10 days using osmotic minipumps (n = 5 for each group). Twenty-four hours after the cessation of dosing, the rats were sacrificed, and brains were removed for analysis of PCP receptor binding. Saturation studies of the binding of [ 3H]-TCP to brain homogenates revealed statistically significant increases in the maximum binding capacity ( B max) and decreases in the affinity for [ 3H]-TCP in the PCP-treated group.
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