Abstract
1. Intoxication of rats with carbicron (O-([2-butenoic acid)-N,N-dimethylamide-3-yl]-O,O-dimethylphosphate) induced a reduction of the total phospholipids and phosphatidylcholine in lung alveolar surfactant. 2. The lipid transfer protein activity was inhibited due to carbicron treatment. 3. No alterations were observed in phospholipase A 2 activity in the alveolar surfactant of intoxicated animals. The structural order parameter (S DPH) of bilayer liposomes, prepared from surfactant phospholipids of carbicron-treated rats also remained unchanged.
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