Abstract
Objective: The aim of the current study was to investigate the alterations in the neural networks of patients with temporal lobe epilepsy (TLE) during working memory (WM) encoding.Methods: Patients with TLE (n = 52) and healthy volunteers (n = 35) completed a WM task, during which 34-channel electroencephalogram signals were recorded. The neural networks during WM encoding were calculated in TLE patients with (TLE-WM) and without (TLE-N) WM deficits.Results: Functional connectivity strength decreased, and the theta network was altered in the TLE-WM group, although no significant differences in clinical features were observed between the TLE-N and TLE-WM groups.Conclusions: Not all patients with TLE present with cognitive impairments and alterations in the theta network were identified in TLE patients with functional cognitive deficits.Significance: The theta network may represent a sensitive measure of cognitive impairment and could predict cognitive outcomes among patients with TLE.
Highlights
Working memory (WM) is a core cognitive function that is vital for higher-level cognition
Functional connectivity strength decreased, and the theta network was altered in the temporal lobe epilepsy (TLE)-WM group, no significant differences in clinical features were observed between the the functional connectivity strength (TLE-N) and TLE-WM groups
Not all patients with TLE present with cognitive impairments and alterations in the theta network were identified in TLE patients with functional cognitive deficits
Summary
The neural networks during WM encoding were calculated in TLE patients with (TLE-WM) and without (TLE-N) WM deficits
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