Abstract
Aim:The aim of this study was to determine the alterations in the lipid profile, plasma alkaline phosphatase (ALP) activity, total and direct bilirubin levels of neonatal calves with diarrhea.Materials and Methods:A total of 25 calves with diarrhea as experimental group and 10 healthy calves as control group, 1-30 days old, were enrolled in the study. Blood samples were collected from jugular vein in tubes with anticoagulant agent to evaluate the concentration of triglycerides, total cholesterol, high-density lipoprotein-cholesterol (HDL-C), ALP, total and direct bilirubin. Very low-density lipoprotein-cholesterol (VLDL-C) and low-density lipoprotein-cholesterol (LDL-C) levels were calculated according to the Friedewald formula.Results:Significant increases in the plasma levels of ALP (p<0.05), total and direct bilirubin, triglycerides, and VLDL-C (p<0.01) were determined, whereas significant decreases in the levels of total cholesterol, HDL-C and LDL-C (p<0.01) were observed in neonatal calves with diarrhea.Conclusion:According to the findings of this study, liver functions impaired and, therefore, lipid profile is affected negatively in neonatal calves with diarrhea.
Highlights
The neonatal period represents a critical stage in the development of physiological functions
Blood samples were collected from jugular vein in tubes with anticoagulant agent to evaluate the concentration of triglycerides, total cholesterol, high-density lipoprotein-cholesterol (HDL-C), alkaline phosphatase (ALP), total and direct bilirubin
Depending on organ or system dysfunction, several metabolic disorders such as metabolic acidosis, hypoglycemia, hyperlactatemia, and hyperfibrinogenemia occur and the severity of these alterations determine the prognosis of the diarrheic calves [21,22]. In view of such consideration, the aim of this study was to evaluate the possible changes in lipid variables, alkaline phosphatase (ALP), and bilirubin values to estimate a possible liver failure in neonatal calves affected by diarrhea
Summary
The neonatal period represents a critical stage in the development of physiological functions. During this phase, the newborn has to face several adjustments to adapt the body systems to extrauterine life [1]. Neonatal diarrhea is a one of the major causes of morbidity and mortality in calves during the first 3 weeks of life, resulting in considerable economic loss. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
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