Alterations in goal-directed behavior but not emotion after lesions of distinct subregions of macaque orbital prefrontal cortex

Abstract

Event Abstract Back to Event Alterations in goal-directed behavior but not emotion after lesions of distinct subregions of macaque orbital prefrontal cortex E. A. Murray1* and P. H. Rudebeck1 1 National Institute of Mental Health, Laboratory of Neuropsychology, United States Damage to the orbital prefrontal cortex (PFo) results in marked changes in goal-directed behavior and affect. Two distinct subregions have been identified within the PFo: 1) the central part of Pfo, areas 11 and 13, and 2) the medial part of PFo, area 14. Although it has been proposed that the functions of the subregions may differ, evidence is limited. To test this possibility we compared rhesus monkeys (Macaca mulatta) with excitotoxic lesions of either areas 11/13 (n=4) or area 14 (n=4) with a group of unoperated controls (n=4). The extent of the lesions was confirmed by T2-weighted MRI. We used two tasks: reinforcer devaluation and extinction of responses to a previously rewarded object. We also evaluated emotional responses to a rubber snake. Monkeys with lesions of area 11/13 were impaired on reinforcer devaluation but not extinction. Monkeys with lesions of area 14 showed the converse result, namely, impairment in extinction but not reinforcer devaluation. All three groups behaved similarly in response the the rubber snake. These preliminary results, which show selective changes in goal directed behavior in the absence of changes in emotion, are in contrast with previous reports of macaques with more extensive PFo lesions. Conference: The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010. Presentation Type: Poster Presentation Topic: Abstracts Citation: Murray EA and Rudebeck PH (2010). Alterations in goal-directed behavior but not emotion after lesions of distinct subregions of macaque orbital prefrontal cortex. Conference Abstract: The 20th Annual Rotman Research Institute Conference, The frontal lobes. doi: 10.3389/conf.fnins.2010.14.00088 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Jun 2010; Published Online: 29 Jun 2010. * Correspondence: E. A Murray, National Institute of Mental Health, Laboratory of Neuropsychology, Bethesda, United States, murraye@mail.nih.gov Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers E. A Murray P. H Rudebeck Google E. A Murray P. H Rudebeck Google Scholar E. A Murray P. H Rudebeck PubMed E. A Murray P. H Rudebeck Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.