Abstract
A comparative electrocardiographic evaluation of changes in cardiac function in rats with hereditary arterial hypertension (NISAG strain) and normotensive (Wistar) rats in response to a single epinephrine injection revealed much more pronounced changes in NISAG rats, including an unfavorable time course of electrocardiographic waves (left ventricle overload) and impaired conduction (blockade) and excitability (extrasystoles). The results indicate that the myocardium of NISAG rats is much more responsive to the acute stimulation of adrenergic receptors by epinephrine than is the myocardium of normotensive rats.
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