Abstract
It was shown in 1955 that the injection of incompatible (human) blood into dogs resulted in alterations in the blood coagulation constituents and mechanism.1These changes included production of a thrombocytopenia, a decrease in number of white blood cells, a prolongation of prothrombin time, prolongation of the clotting time, a decrease in fibrinogen, and the appearance of a circulating heparinoid anticoagulant. Little or no fibrinolysin was evident. It was also demonstrated2,3that the injection of incompatible blood caused an episode of intravascular coagulation in the small vessels and capillaries. It was postulated1,16that the changes in the blood constituents and clotting mechanism were due to the using up of clotting elements by an episode of intravascular clotting and that the appearance of a heparinoid anticoagulant was a mechanism of defense by the body against the clotting episode. Because of the protean components of blood, the current interest
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
