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Abstract
The effect of short periods of starvation on adrenal function was evaluated in a group of obese females. Normal plasma cortisol levels were maintained during the fast period, while urinary excretion of 17-hydroxycorticoids, 17-ketosteroids, and unconjugated 11-hydroxycorticoids fell. Evidence indicates that a reduction of cortisol secretion occurs during brief periods of fasting. In addition, the measurement of urinary 11-hydroxycorticoids may be a rapid and efficient method for differentiating exogenous obesity from Cushing's syndrome.
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