Abstract
Uterine corpus endometrial carcinoma (UCEC) is one of the most common cancer in female worldwide. PIK3CA has been proven to be a strong prognostic biomarker in UCEC. Nevertheless, current studies have not investigated what effects PIK3CA had on tumor associated neutrophils (TANss). Kaplan-Meier methods were used to compute the survival time of TCGA UCEC patients. GO and KEGG enrichment analysis unveiled relevant pathways PIK3CA affected using DEGs between PIK3CA high expression group and PIK3CA low expression group in TCGA UCEC, as well as GSEA. immune infiltration status was calculated using TIMER. We found that PIK3CA influenced a number of pathways including immune related pathways. The fraction of TANs was certainly altered by PIK3CA expression in UCEC. Our findings suggest that PIK3CA expression may play an important role in tumor immune microenvironment and could alter fraction of TANs in UCEC.
Highlights
Uterine corpus endometrial carcinoma (UCEC) is the most common gynecologic malignancy in plenty of countries, 9 out of 10 women with early-stage disease present with the symptom of postmenopausal bleeding [1]
Expression level of PIK3CA was correlated with survival time of UCEC patients The Human Protein Atlas showed the expression of PIK3CA in UCEC varied from medium to high and mainly in cytoplasm (Fig. 1a)
Kaplan-Meier Survival Analysis [15] of 542 The Cancer Genome Atlas (TCGA) UCEC patients grouped by the expression of PIK3CA revealed a poorer clinical outcome in patients with high PIK3CA expression compared to those with low PIK3CA expression (P = 0.0018) (Fig. 1b)
Summary
Uterine corpus endometrial carcinoma (UCEC) is the most common gynecologic malignancy in plenty of countries, 9 out of 10 women with early-stage disease present with the symptom of postmenopausal bleeding [1]. Over 50,000 women die from UCEC every year in the world [2]. PI3K pathway serves a pivotal function that may have potential for defining targeted therapy for the treatment of grade 3 UCEC [4]. The main component of PI3K pathway, PIK3CA, is a strong prognostic biomarker in UCEC and associates with disease-specific mortality [5]. PIK3CA missense mutation is associated with unfavorable outcome in endometrioid carcinoma [6, 7]. PIK3CA and PIK3R1 mutations were frequent and showed a strong tendency for mutual exclusivity in UCSC [8]. The previous work on molecular mechanism of UCEC has indicated that PIK3CA played a crucial role in development of tumor
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