Abstract
Effect of several kinds of metal ions on the chain-length distribution of reaction products of polyprenyl diphosphate synthases was investigated. In the presence of Co 2+ or Mn 2+ octaprenyl-, solanesyl- and decaprenyl diphosphate synthases gave a variety of polyprenyl products with the longest chains being shifted by one or two isoprene units longer than those of the products formed in the presence of Mg 2+. Thus octaprenyl diphosphate synthase became to give solanesyl (C 45) and decaprenyl (C 50) diphosphates when Mg 2+ is replaced with Co 2+ or Mn 2+. Similarly solanesyl diphosphate synthase produced C 50- and C 55-diphosphates in the presence of Co 2+ or Mn 2+, and decaprenyl diphosphate synthase gave C 55-diphosphate as the longest product in the presence of Mn 2+. More remarkable effects were observed with Mn 2+ than with Co 2+.
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