Alteration of immune status during treatment with β-blockers in patients with essential hypertension

Abstract

The balance of cytokines (IL-2, IL-10, IF-γ) in patients with essential hypertension beforeandaftertreatmentwithβ-blockerswasstudied.20patientsaged45-65yearsbefore and after treatment with β-blockers was studied. 20 patients aged 45-65 years anddiagnosedwithessentialhypertension(12women,8men)wereinvestigated.Forand diagnosed with essential hypertension (12 women, 8 men) were investigated. For thetreatmentofhypertension,patientsreceivedsecond-generationbeta-selectivethe treatment of hypertension, patients received second-generation beta-selective β-blockersEgilokandBetalokZok,andthird-generationβ-blockerNebiletforoneβ-blockers Egilok and Betalok Zok, and third-generation β-blocker Nebilet for one month.Patientsperformedtheirbloodpressuremeasurementsdailyinthemorningmonth. Patients performed their blood pressure measurements daily in the morning duringImonth.Thecontentofinterleukins(IL-2,IL-10,IF-γ)inthebloodbytheduring I month. The content of interleukins (IL-2, IL-10, IF-γ) in the blood by the immuneenzymaticELISAmethodonasemi-automaticreaderStatFax3200withimmune enzymatic ELISA method on a semi-automatic reader Stat Fax 3200 with RayBio,(USA)reagentwasmeasured.TheresultsofourstudiesshowanincreaseRayBio, (USA) reagent was measured. The results of our studies show an increase inthelevelofCD4+(IL-2)cytokinesinthebloodofthestudiedhypertensivein the level of CD4+ (IL-2) cytokines in the blood of the studied hypertensive patients,whichcoincideswiththeliteraturedataontheimportantroleofCD4+patients, which coincides with the literature data on the important role of CD4+ pro-inflammatorycytokinesinthepathogenesisofhypertension.After1monthofpro-infl ammatory cytokines in the pathogenesis of hypertension. After 1 month of treatmentwithβ-blockers,thepatient’sarterialpressureandIL-2levelcontentintreatment with β-blockers, the patient’s arterial pressure and IL-2 level content in theblooddecreased.Thesedataindicatetheimportantroleofinflammationinthethe blood decreased. These data indicate the important role of infl ammation in the pathogenesisofhypertensionandtheanti-inflammatoryeffectsofβ-brokers,usedpathogenesis of hypertension and the anti-infl ammatory effects of β-brokers, used inthetreatmentofhypertension.in the treatment of hypertension