Abstract
BackgroundImaging studies have provided valuable information in understanding the headache neuromechanism for medication-overuse headache (MOH), and the aim of this study is to investigate altered texture features of MR structural images over the whole brain in MOH using a 3-dimentional texture analysis.MethodsBrain three-dimensional T1-weighted structural images were obtained from 44 MOH patients and 32 normal controls (NC). The imaging processing included two steps: gray matter (gray images) segment and a 3-dimensional texture features mapping. Voxel-based gray-level co-occurrence matrix (VGLCM) was performed to measure the texture parameters mapping including Contrast, Correlation, Energy, Entropy and inverse difference moment (IDM).ResultsThe texture parameters of increased Contrast and Entropy, decreased Energy and IDM were identified in cerebellar vermis of MOH patients compared to NCs. Increased Contrast and decreased Energy were found in left cerebellum. Increased Correlation located in left dorsolateral periaqueductal gray (L-dlPAG), right parahippocampal gyrus (R-PHG), and left middle frontal gyrus (L-MFG) and decreased Correlation located in right superior parietal lobule(R-SPL). Disease duration was positively correlated with Contrast of vermis and negatively correlated with Correlation of R-SPL.HAMD score was negatively correlated with Correlation of R-PHG. MoCA score was positively correlated with Correlation of R-SPL.ConclusionThe altered textures in gray matter related to pain discrimination and modulation, affective and cognitive processing were helpful in understanding the pathogenesis of MOH. Texture analysis using VGLCM is a sensitive and efficient method to detect subtle gray matter changes in MOH.
Highlights
Imaging studies have provided valuable information in understanding the headache neuromechanism for medication-overuse headache (MOH), and the aim of this study is to investigate altered texture features of MR structural images over the whole brain in MOH using a 3-dimentional texture analysis
Significant increased Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scores and decreased Montreal Cognitive Assessment (MoCA) score were identified in MOH compared with normal controls (NC) (P < 0.05)
Voxel-based comparison of contrast map between MOH and NC Regional increased Contrast located in the right cerebellar Crus and Vermis in MOH compared with NC (Table 2 and Fig. 3)
Summary
Imaging studies have provided valuable information in understanding the headache neuromechanism for medication-overuse headache (MOH), and the aim of this study is to investigate altered texture features of MR structural images over the whole brain in MOH using a 3-dimentional texture analysis. The common MRI technique about headache included conventional T2WI [5], advanced brain structure segment [6–8], Chen et al The Journal of Headache and Pain (2017) 18:112 resting-state functional MRI [9], and diffusion kurtosis imaging (DKI) [10], which provided much more valuable information to understand the headache neuromechanism. This advanced MRI technique may consume much more labour and time, and some functional test might be influenced by some uncontrolled state such as motion and emotion
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