Abstract
Methamphetamine (METH) is a stimulant of the central nervous system that damages the genital system. This study was conducted to evaluate changes in expression levels of collagen type IV and laminin α5 after METH administration in the testis of adult mice. METH decreased the RNA expression of collagen type IV and laminin α5. In addition, the collagen IV and laminin α5 protein level in the seminiferous tubules of the METH group was decreased significantly. It seems that METH negatively affects fertility by reducing the expression of collagen type IV and laminin α5 and alters the contents of the extracellular matrix (ECM).
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