Alteration of Angiopoietin-Like Protein 4 Levels in Serum or Urine Correlate with Different Biochemical Markers in Hyperlipidemia-Related Proteinuria.

Xia Gao,Yan Wang,Min Zhang,Weidong Feng,Zichuan Xu,Jing Zhang,Lingna Shi

doi:10.1155/2020/5281251

Abstract

Angiopoietin-like protein 4 (ANGPTL4) is widely known as a key regulator of lipid metabolism. We investigated the relationship between ANGPTL4 expression in serum or urine and blood lipid or urine protein levels of patients with hyperlipidemia- (HL-) related proteinuria. Sixty-eight patients with HL-related proteinuria (HL-Pro group), 68 patients with HL without proteinuria (HL-NPro group), 46 patients with non-HL-related proteinuria (NHL-Pro group), and 50 healthy control (Con) subjects were selected. There were no significant differences in serum ANGPTL4 levels between the Con group (36.82 ± 17.03 ng/ml) and the HL-Pro group (27.94 (18.90, 53.72) ng/ml). Additionally, the serum ANGPTL4 levels in the HL-Pro group were significantly lower than those in the HL-NPro group (53.32 ± 24.01 ng/ml) (P < 0.001). The urine ANGPTL4/Cr levels in the HL-Pro group (52.01 (45.25, 79.79) μg/g) were significantly higher than those in the HL-NPro group (9.96 (8.35, 12.43) ng/ml) (P < 0.05). A significant alteration in urine ANGPTL4/Cr levels was observed in the NHL-Pro group (69.41 ± 55.36 μg/g) and the Con group (10.08 ± 2.38 μg/g) as well. There was no correlation between serum and urine ANGPTL4 levels of the four groups (P > 0.05). Serum ANGPTL4 levels (HL-Pro/HL-NPro group) were positively correlated with total cholesterol (TC) and triglyceride (TG) levels in hyperlipidemia patients. However, there was no correlation between urinary ANGPTL4 levels and TC or TG (P > 0.05). Urine ANGPTL4 levels were positively correlated with 24hUPro in patients with renal impairment (HL-Pro/NHL-Pro group). To summarize, ANGPTL4 may be considered an accurate predictor of proteinuria with HL. Notably, serum or urine ANGPTL4 levels indicated the degree of proteinuria or hyperlipidemia, respectively, in HL patients.

Highlights

It was first confirmed more than 30 years back that the apolipoprotein APOA1 and APOB had a role in renal expression [1]
We first analyzed the possible correlation between serum or urine Angiopoietin-like protein 4 (ANGPTL4) levels and the primary indicators of serum lipids in patients with HL-related proteinuria; we further explored the possible relationship between serum or urine ANGPTL4 and urinary protein levels
The average age of the Con group was lower than that of the other three groups, and the difference was statistically significant (P < 0:05), suggesting that the incidence of dyslipidemia and proteinuria increased with age in a statistically significant manner (P < 0:05)

Summary

Introduction

It was first confirmed more than 30 years back that the apolipoprotein APOA1 and APOB had a role in renal expression [1]. Recent studies have demonstrated that glomerulus mesangial cells and podocytes could express lipid metabolism proteins, suggesting that the kidney is one of the sources of lipoprotein secretion as well [4]. ANGPTL4 functions as a key regulator of lipid metabolism and its role has been widely reported in metabolic diseases and cardiovascular diseases [6, 7]. Some studies have reported that ANGPTL4 plays a significant role in tumor invasion, intestinal microecological regulation, fracture healing, and tendon cell proliferation, adhesion, and migration [8,9,10,11]. Clement et al [12,13,14] confirmed that sialylated ANGPTL4

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