Abstract
SummaryBackgroundThere is a paucity of studies regarding oxidative balance and selenium (Se) status in congenital hypothyroidism. Recently, more attention has been given to the use of Se supplementation as a new treatment for thyroid disorders. Oxidative stress increases in different thyroid disorders and causes many pathological outcomes. The present study aimed to determine the serum prooxidant-anti - oxidant balance (PAB), Se, thyroid stimulating hormone (TSH) and free thyroxine (FT4) concentration in congenital hypothyroidism (CH) patients and the association of their probable change with hematological indices.MethodsBlood samples were collected from 60 healthy and 39 CH subjects. Serum PAB values were measured and Se, TSH, FT4 and hematological indices were determined. Data were analyzed by SPSS version 16 and p value less than 0.05 was considered statistically significant.ResultsSerum TSH concentration was significantly higher in CH patients group compared to the controls (p value < 0.05); however, FT4 was in the same concentration in patients and controls. Platelet (Plt) and lymphocytes (Lym) counts markedly decreased in all patients and showed a significant direct correlation with serum TSH levels (rs = 0.307, p value = 0.004 and rs = 0.413, p value < 0.0001). Serum PAB and Se had no significant correlation with he - mato logical indices in the studied subjects.ConclusionsAlthough there was no correlation between PAB and also Se with hematologic and biochemical markers in CH patients, changes in these two factors might be considered as a potential risk factor due to the other known effects of high PAB values and low Se concentrations.
Highlights
Thyroid hormones have a significant effect on modifying the oxidant-antioxidant balance
In a routine neonatal screening for thyroid disorders, newborn screening was done with filter paper for congenital hypothyroidism (CH) between 72 h and 7 days past birth; blood samples were collected from the heel and thyroid-stimulating hormone (TSH) level was measured; positive results were confirmed by measurement of serum TSH and free T4 using an enzyme-linked immunosorbent assay (ELISA)
Thirty-nine CH patients and 60 healthy children were enrolled in the study as case and control groups
Summary
Thyroid hormones have a significant effect on modifying the oxidant-antioxidant balance. In the case of congenital hypothyroidism (CH), neurodegenerative complications are highly associated with oxidative stress. Alteration of selenium (Se) concentration in thyroid disorders has been considered in recent years; the possible association between Se concentration and congenital hypothyroidism remains unclear. Some evidence showed alteration of hematologic indices in thyroid disorders (8 –10). Our previous study showed that higher oxidant levels link to changes in hematologic indices like white blood cells (WBC) count, red blood cells (RBC) count and hemoglobin (Hb) concentration [11, 12]. Concerning the hypothyroid patients, some studies showed that total leucocyte, neutrophils and platelets count may be slightly serumu (rs = 0,307, p vrednost = 0,004 i rs = 0,413, p vrednost < 0,0001). Zaklju~ak: Iako nije bilo korelacije izme|u PAB niti Se i hematolo{kih i biohemijskih markera kod obolelih od CH, promene ova dva faktora mogle bi se smatrati za potencijalni faktor rizika zbog drugih poznatih efekata visoke vrednosti PAB i niske koncentracije Se
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