Abstract
Summary In a patient with obstructive jaundice secondary to extrahepatic biliary obstruction due to metastatic cancer of the liver, it was found that the delicate balance for energy production was maintained by the enhancement of mitochondrial metabolism and that a progressive decrease in the contents of cytochromes a(+a 3 ) and b of the liver mitochondria developed with a deterioration of the physical status. The same sequence for energy balance in the liver mitochondria also was observed in the liver of rabbits that had major damage induced by experimental ligation of the left hepatic bile duct.
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