Abstract
AbstractLambdacyhalothrin (LCT), a type II pyrethroid pesticide, is an efficacious pesticide. Its use in the environment has increased tremendously. Acute and chronic toxic effects of LCT were evaluated in male Rattus norvegicus. Lethal doses (LD) were determined and chronic effects on haematological and biochemical indices, sperm count, motility and morphology and histology of testes were evaluated using 5, 10, 20 and 40% of 96 h LD50. The 96 h LD50 value obtained for treated rats was 9.625 mg/kg bw. A significant reduction in values of packed cell volume, haemoglobin and red blood cell count was observed. Marked effects on haematological indices were at 1.925 and 3.850 mg/kg bw as the period of evaluation increased. Increase in mean cell volume and mean cell haemoglobin with slight variations in rats treated with 1.925 and 3.850 mg/kg bw indicates macrocytic anaemia. Increased serum glucose and cholesterol levels were observed, while a significant reduction in total protein and globulin was dose-depende...
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