Abstract
Background: Subjective memory impairment (SMI) may precede a mild cognitive impairment (MCI) stage and would offer an earlier therapeutic opportunity than MCI would. Although a primary emphasis has been placed on memory disability and its related brain regional deficits with SMI, there is an undergoing controversy on the nature of SMI because it is not clear whether complaints of forgetfulness are truly reflective of objective memory dysfunction or of impairments in other cognitive domains.
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