Abstract
to determine the prevalence of histopathological changes, in human placentas, related to hypertensive syndromes. a transversal study that compares histopathological changes identified in 43 placentae from hypertensive pregnant women (HypPr), with the ones from 33 placentae from normotensive pregnant women (NorPr). The weight, volume and macroscopic and microscopic occurrence of infarctions, clots, hematomas, atherosis (partial obliteration, thickness of layers and presence of blood vessels hyalinization) and Tenney-Parker changes (absent, discreet and prominent), as well as the locating of infarctions and clots (central, peripheral or the association of both) have been analyzed. The chi2 and t Student tests have been used for the statistical analysis, as well as medians, standard deviations and ratios. It has been considered as significant, p<0.05. the macroscopic study of HypPr placentae have presented lower weight (461.1 versus 572.1 g) and volume (437.4 versus 542.0 cm(3)), higher infarction (51.2 versus 45.5%; p<0.05: OR=1.15) and clots (51.2 versus 15.1%; p<0.05; OR=5.4) ratios, as compared to the NorPr's. In the HypPr and NorPr, microscopic clots have occurred in 83.7 versus 45.5% (p<0.05; OR=4.3), respectively. Atherosis and Tenney-Parker changes have been statistically associated to the hypertensive syndromes (p<0.05). the obtained data allow us to associate lower placentary weight and volume, higher ratio of macro and microscopic infarction, clots, atherosis and Tenney-Parker changes to placentae of gestations occurring with hypertensive syndromes.
Highlights
PURPOSE: to determine the prevalence of histopathological changes, in human placentas, related to hypertensive syndromes
Foram observadas em placentas de gestantes hipertensas lesões características nas arteríolas dos troncos vilosos, representadas por hiperplasia da camada muscular e forte espessamento do tecido conjuntivo subendotelial, com proliferação fibrocitária e invasão leucocitária, que originou progressiva obstrução da luz dos vasos[2]
Os dados obtidos permitem associar a presença de maior percentual de infartos, coágulos, hematomas, aterose e alterações de Tenney-Parker, bem como menor peso e volume placentários, com as síndromes hipertensivas
Summary
PURPOSE: to determine the prevalence of histopathological changes, in human placentas, related to hypertensive syndromes. Com o objetivo de determinar a prevalência das alterações histopatológicas em placentas humanas relacionadas às síndromes hipertensivas, realizou-se estudo de corte transversal, no período de janeiro de 2003 a dezembro de 2004, no Serviço de Ginecologia e Obstetrícia do Hospital Geral da Universidade de Caxias do Sul. Para tanto, foi realizada análise macro e microscópica de 43 placentas oriundas de gestantes hipertensas e que foram denominadas de grupo hipertenso (GrHip).
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