ALT chimeric flap associated to a dura mater biomatrix substitute for severe desfigurative mandible osteoradionecrosis and deficient bone consolidation after a free fibula flap

Abstract

Although radiotherapy can increase cure rates after head and neck cancer it often comes with secondary effects, one of the worst of which is osteoradionecrosis. Obliterative endarteritis, hyperaemia, hyalinisation, cellular loss, hypovascularisation, thrombosis, and fibrosis are common histological findings. Bone cells are damaged as a result of acute inflammation, free radicals, and the chronic activation of fibroblasts. 1 Lyons A. Ghazali N. Osteoradionecrosis of the jaws: current understanding of its pathophysiology and treatment. Br J Oral Maxillofac Surg. 2008; 46: 653-660 Abstract Full Text Full Text PDF PubMed Scopus (196) Google Scholar