Abstract
目的 观察前列地尔对尘肺肺心病患者血液流变学及呼吸功能的影响.方法 将80例尘肺肺心病患者,随机分为治疗组(41例)和对照组(39例),治疗组予给氧、抗生素、激素、利尿剂等药物常规治疗及前列地尔(10 μg+5％葡萄糖250 ml,静脉滴注),1次/日,14d为1疗程,共2个疗程；对照组给予常规治疗,观察两组血液流变学、血凝[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血浆凝血酶时间(TT)]、肺功能[用力肺活量(FVC)、第1秒用力呼气容积(FEV1.0)、FEV10/FVC]、血气分析[氧分 压(PaO2)、二氯化碳分压(PaCO2)]等指标的变化.结果 与治疗前治疗组[FEV1.0:52.33％±9.82％、FEV1.0/FVC:52.72％± 10.03％、FVC:50.70％±8.52％、PaO2:52.17％±8.91％、PaCO2:74.32％±9.25％]和治疗后对照组[FEV1.0:63.41％ ±10.15％、FEV1.0/FVC:60.23％ ±10.35％、FVC:61.20％ ±9.39％、PaO2:66.91 ±9.58％、PaCO2:65.23％±8.31％]比较,治疗后治疗组FEV1.0:(72.81％±10.45％)、FEV1.0/FVC:(70.21％±11.30％)、FVC:(71.62％±10.30％)、PaO2:(75.38％±10.31％)升高,PaCO2:(56.14％±7.39％)降低,差异均有统计学意义(P＜0.05).与治疗后对照组和治疗前治疗组比较,治疗后治疗组PT、APTT、TT升高,低切变率全血黏度、高切变率全血黏度、红细胞压积、纤维蛋白原降低,差异均有统计学意义(P＜0.05).结论 在常规治疗基础上,应用前列地尔在一定程度上改善血液黏滞性和肺功能。
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