Abstract
Progesterone has long been advocated as a treatment for premenstrual syndrome (PMS) despite a lack of scientific support. The negative results from many clinical trials have been attributed to problems with the vaginal suppository route of administration. Alprazolam is also used to treat PMS, although results from controlled clinical trials have been mixed. Both of these agents are more attractive than antidepressants because they are required during the luteal phase …
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