Abstract
No abstract available
Highlights
Benzodiazepine receptors are coupled with GABA-A receptors, and by this mechanism benzodiazepines enhance the effects of GABA by increasing GABA affinity at the GABA receptor.[2]
We present a 65 year old retired bank officer with depressive disorder, who was admitted to the Psychiatry unit, District General Hospital, Matara in a state of withdrawal delirium after being on alprazolam for eight years
After explaining Sarath and family members the harmful effects of long term use of alprazolam and the drug was replaced with diazepam which is a long acting benzodiazepine, with the aim of gradually withdrawing him from regular benzodiazepine use
Summary
Benzodiazepine receptors are coupled with GABA-A receptors, and by this mechanism benzodiazepines enhance the effects of GABA by increasing GABA affinity at the GABA receptor.[2]. If a person has been on a benzodiazepine for more than three or four weeks, he or she is likely to experience withdrawal symptoms if the drug is stopped abruptly.[1] Patients tend to develop dependence and tolerance to benzodiazepines on prolonged use.[4] Long term use of benzodiazepines gives rise to dose escalation and worsening of the underlying condition.[1] We present a 65 year old retired bank officer with depressive disorder, who was admitted to the Psychiatry unit, District General Hospital, Matara in a state of withdrawal delirium after being on alprazolam for eight years.
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