Abstract
Alpha-bisabolol, not a matter for cancer therapy. Commentary: "Research on the immunosuppressive activity of ingredients contained in sunscreens".
Highlights
A recent paper showed that bisabolol contained in cosmetics drastically dampened peripheral blood lymphocyte proliferation induced by phytohemoagglutinin (PHA) and enhanced the production of tumor growth factor-beta 1 (TGF-β1) on NCTC 2544 keratinocytes, it did not change the activity of monocytes and dendritic cells (Frikeche et al, 2015)
The authors showed that some organic molecules present in sunscreens impaired dendritic cells (DCs) maturation, or inhibited lymphocyte proliferation as well as increased of TGF-β1 in the cell environment
Darra et al, reported that the anti-neoplastic action exerted by α-bisabolol, derives fundamentally by its ability in inducing mitochondria-mediated apoptosis in cancer cells (Darra et al, 2007, 2008; Cavalieri et al, 2009)
Summary
A recent paper showed that bisabolol contained in cosmetics drastically dampened peripheral blood lymphocyte proliferation induced by phytohemoagglutinin (PHA) and enhanced the production of tumor growth factor-beta 1 (TGF-β1) on NCTC 2544 keratinocytes, it did not change the activity of monocytes and dendritic cells (Frikeche et al, 2015). The authors showed that some organic molecules present in sunscreens impaired DC maturation, or inhibited lymphocyte proliferation as well as increased of TGF-β1 in the cell environment.
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