Abstract
To confirm the effectiveness of the 10B delivery system, it is required to achieve an accurate measurement of 10B concentrations in biological samples with a sensitivity in the ppm range for boron neutron-capture therapy (BNCT). We applied CR-39 plastic track detectors to alpha-autoradiographic measurements of the 10B biodistribution in sliced whole body samples of pancreatic cancer bearing mice. CR-39 can record the energetic heavy charged particles generating from the 10B (n,α) 7Li reaction, as well as neutron induced recoil protons which disturb alpha-radiographic imaging and alpha-track counting as background tracks. To desensitize unwanted proton tracks selectively we applied PEW (KOH + C2H5OH + H2O) solution to the etching of CR-39 detector. The discrimination between alpha-tracks and recoiled proton tracks was made by track size selection method. This enabled to estimate quantitatively the distributions of 10B concentrations within the tissue sections comparing with the standards.
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