Alpha‐synuclein and Parkinson's disease: Implications from the screening of more than 1,900 patients

Daniela Berg,Rejko Krueger,Ted M Dawson,Marc Niwar,Bernd Janetzky,Ullrich Wuellner,Tanja Schmitz‐Hübsch,Christine Klein,Alexander Zimprich,Dirk Woitalla,Laura Marsh,Wolfgang H Oertel,Thomas Müller,J Carsten Möller,Peter P Pramstaller,Peter Bauer,Thomas Gasser,Lüdger Schöls ,Eng King Tan ,Vladimir Kostić ,Sylvia Maaß ,Olaf Rieß

doi:10.1002/mds.20504

Alpha‐synuclein and Parkinson's disease: Implications from the screening of more than 1,900 patients

Daniela Berg, Rejko Krueger + Show 20 more

https://doi.org/10.1002/mds.20504

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Journal: Movement Disorders	Publication Date: May 13, 2005
Citations: 67

Affiliation: Hertie Institute for Clinical Brain Research, University of Tübingen, Johns Hopkins Medicine, Johns Hopkins University, TU Dresden, Singapore General Hospital, University of Bonn, University of Lübeck, Medical University of Vienna, Philipps University of Marburg, University of Belgrade, Ludwig-Maximilians-Universität München, Ospedale di Bolzano, Eurac Research

#Majority Of Parkinson's Disease Patients #Parkinson's Disease + Show 8 more

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Abstract

Data on the frequency of alpha-synuclein mutations in Parkinson's disease (PD) are limited. Screening the entire coding region in 1,921 PD patients with denaturing high performance liquid chromatography and subsequent sequencing we only detected silent mutations (g.2654A>G, g.10151G>A, and g.15986A>T) and the c.209G>A substitution corresponding to the p.A53T mutation. These results demonstrate that mutations in the alpha-synuclein gene are rare and suggest that other factors contribute to alpha-synuclein aggregation in the majority of PD patients.

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