Abstract
The reaction of N-(sulfonyloxy) amides with bases proceeds by initial formation of an α-lactam intermediate. A primary kinetic deuterium isotope effect, k H /k D =2.17. a leaving group effect. β 1g CH3 =0.50, and nucleophilic trapping all confirm that the α-lactam is produced in the rate-determining step. Ring opening to an ion pair and nucleophilic addition to C-2 produce 2-substituted amide products
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
