Abstract
PurposeThe purpose of this study was to clarify the factors that influence the incidence of colorectal neoplasia in patients with type 2 diabetes mellitus (DM).Study Design and SettingAmong a total of 1176 patients who underwent total colonoscopy at our hospital, we retrospectively analyzed 168 patients with type 2 DM. Univariate and multivariate logistic regression analyses were then performed to identify the risk factors associated with colorectal neoplasia.ResultsA multivariate analysis of these patients demonstrated that male gender (odds ratio [OR] = 4.04, 95% confidence interval [CI] = 1.67–10.37, p = 0.002), taking statins (OR = 4.59, 95% CI = 1.69–13.43, p = 0.003), taking alpha glucosidase inhibitor (α-GI) (OR = 0.35, 95% CI = 0.13–0.87, p = 0.023) and taking low-dose aspirin (LDA) (OR = 0.32, 95% CI = 0.10–0.95, p = 0.040) were independent factors associated with an increased (male gender and statins) or decreased (α-GI and LDA) risk of colorectal neoplasia.ConclusionsWhile male gender and taking statins are risk factors, taking α-GI as well as LDA may reduce the risk of colorectal neoplasia in patients with type2 DM.
Highlights
Colorectal cancer (CRC) is a major global healthcare problem, including in Japan; the mortality rate of patients with CRC is twice that of 20 years ago
A multivariate analysis of these patients demonstrated that male gender, taking statins (OR = 4.59, 95% CI = 1.69–13.43, p = 0.003), taking alpha glucosidase inhibitor (α-GI) (OR = 0.35, 95% CI = 0.13–0.87, p = 0.023) and taking low-dose aspirin (LDA) (OR = 0.32, 95% CI = 0.10–0.95, p = 0.040) were independent factors associated with an increased or decreased (α-GI and LDA) risk of colorectal neoplasia
While male gender and taking statins are risk factors, taking α-GI as well as LDA may reduce the risk of colorectal neoplasia in patients with type2 diabetes mellitus (DM)
Summary
Colorectal cancer (CRC) is a major global healthcare problem, including in Japan; the mortality rate of patients with CRC is twice that of 20 years ago. The prevention of colorectal adenoma development by determining the environmental risk factors and identifying high-risk patients might be significant in reducing the rate of death caused by CRC. Accumulating evidence shows that a Western diet (imbalanced diet), sedentary lifestyle, alcohol consumption, tobacco use, lack of physical activity, sleep deprivation and obesity are significant risk factors for CRC [4,5,6]. Among these risk factors, obesity and its related medical problems, especially type 2 diabetes mellitus (DM), are well known to play a critical role in the development of CRC
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