Abstract
Alpha-fetoprotein (AFP) is a reliable tumor marker for the diagnosis and monitoring of primary hepatoceller carcinoma and yolk sac tumors. Elevated serum AFP levels have also been frequentlly reported in patients with carcinoma of the stomach, pancreas, bile duct, duodenum, colon and rectum. Though most of these disease are of the fore-gut derivations, colorectal lesions are hind-gut derivations and AFP-producing carcinoma of a colorectal lesions are rare. We report one case of AFP producing carcinoma that originated in the transverse colon. The patient is a 73-year-old man with a chief complaint of general fatigue. CT scanning determined a diagnosis of transverse colon cancer, therefore transverse colon resection, partial gastrectomy and partial ileum resection were performed. Histologic examination of the transverse colon showed poorly differentiated adenocarcinoma and immunohistochemical staining detected AFP-producing cells. To our knowledge, AFP-producing colorectal carcinoma were reported in 38 cases in the Japanese literature.
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