Abstract
1. Rabbit white fat cells, in vitro, may not respond to epinephrine by an increase in the rate of lipolysis. 2. However, isoproterenol exerts a strong adipokinetic effect competitively inhibited by propranolol, thus revealing β-adrenergic receptors. 3. When basal rate of lipolysis is high, antilipolytic effect can be shown for low concentrations of epinephrine. 4. The best evidence of these results is that inhibitory α-adrenoceptors are involved in rabbit white fat cells, their stimulation by epinephrine leading to a depressive effect on lipolysis; this effect can be suppressed by an α-adrenolytic, phentolamine.
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