Abstract
Thirteen plant species which are claimed to have anti-diabetic activity (based on folk medicine and/or scientific reports) were tested for alpha amylase inhibitory activity. Two of the screened plants exhibited significant (more than 80%) alpha amylase inhibitory activity. lC50 of these plants was estimated based on the dried crude extract and found to be 0.08, and 0.2 mg/ml for Aloe vera and Paronychia argentea respectively. In A. vera the activity was most likely due to cinnamic acid derivatives. In P. argentea the activity was attributed to flavonoid components. These findings support the hypoglycemic activity of these species and give insight about the potential mechanism of their hypoglycemic activity.
Highlights
Several plant species have been advocated in the Jordanian folk medicine for their hypoglycemic effects [I]
The hypoglycemic effect of some of these plants have been supported by scientific studies on experimental animals [2-71
Thirteen plant extracts were tested for alpha amylase inhibitory activity using a literature method that was optimized and validated in the author's labs [13]
Summary
Several plant species have been advocated in the Jordanian folk medicine for their hypoglycemic effects [I]. The aim of this study was to screen some plants commonly used in the folk medicine in Jordan in a search for new alpha amylase inhibitors and to give insight concerning the mechanism of their potential hypoglycemic activity. The obtained extract was centrifuged and filtered before being subjected to alpha amylase inhibitory test.
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