Year-end Sale % OFF 
Abstract
BackgroundNo clear consensus has been reached on the alpha-adducin polymorphism (Gly460Trp) and essential hypertension risk. We performed a meta-analysis in an effort to systematically summarize the possible association.Methodology/Principal FindingsStudies were identified by searching MEDLINE and EMBASE databases complemented with perusal of bibliographies of retrieved articles and correspondence with original authors. The fixed-effects model and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. We selected 22 studies that met the inclusion criteria including a total of 14303 hypertensive patients and 15961 normotensive controls. Overall, the 460Trp allele showed no statistically significant association with hypertension risk compared to Gly460 allele (P = 0.69, OR = 1.02, 95% CI 0.94–1.10, Pheterogeneity<0.0001) in all subjects. Meta-analysis under other genetic contrasts still did not reveal any significant association in all subjects, Caucasians, East Asians and others. The results were similar but heterogeneity did not persist when sensitivity analyses were limited to these studies.Conclusions/SignificanceOur meta-analysis failed to provide evidence for the genetic association of α-adducin gene Gly460Trp polymorphism with hypertension. Further studies investigating the effect of genetic networks, environmental factors, individual biological characteristics and their mutual interactions are needed to elucidate the possible mechanism for hypertension in humans.
Highlights
Essential hypertension (EH) is a major global public health problem which affects a large proportion of adult population worldwide
Description of studies identified in meta-analysis The initial search strategy for hypertension susceptibility related to the alpha-adducin single nucleotide polymorphism (SNP) yielded 152 potentially relevant references in PubMed and 158 in EMBASE, most of which were overlapping
[22] Only one paper by Province et al [23] included separate data on subjects of two ethnicities: European-American and AfricanAmerican, the genotyping data in the population of European-American was deviated from Hardy–Weinberg equilibrium (HWE) (PHWE = 0.000522), as well as in the population of Asian provided in Ramachandran et al [34] (PHWE = 0.001644)
Summary
Essential hypertension (EH) is a major global public health problem which affects a large proportion of adult population worldwide. The role of alpha-adducin (ADD1) in hypertension and other cardiovascular diseases has been extensively evaluated, paying particular attention to the rs4961 (Gly460Trp, G460W or G460T) single nucleotide polymorphism (SNP) at exon 10 on chromosome 4p16.3 [5], in which a guanine-to-thymine transversion at nucleotide 614 leads to a glycine (Gly) to tryptophan (Trp) substitution at amino acid position 460. Some have reproduced the supportive association between Gly460Trp polymorphism and EH or blood pressure (BP) level [6,7,8,9], whereas others were unable to replicate these findings [10,11,12,13,14]. We performed a meta-analysis in an effort to systematically summarize the possible association
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
