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Abstract
Alpha 2-adrenergic receptor function was measured in platelets from unipolar (UP) depressed, bipolar (BP) depressed, and bipolar euthymic patients and normal control subjects. Only the platelets from UP depressed patients were different from control in having an increased number of α 2-receptors, a decreased percent norepinephrine inhibition of prostaglandin E 1 (PGE 1)-stimulated cyclic AMP (cAMP) production, and a decrease in PGE 1 stimulation of cAMP production. Platelets from BP patients, depressed or euthymic, were not significantly different from control subjects. These preliminary data suggest that α 2-adrenergic receptor function and PGE 1 stimulation of cAMP production are diminished in UP patients.
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