Abstract
PURPOSE: Alpha-1 Antitrypsin (AAT) deficiency is one common lethal genetic cause of emphysema in adults. The World Health Organization (WHO) recommends detection of AAT level in patients with Chronic Obstructive Pulmonary Disease (COPD) and Asthma. The abnormally low plasma concentrations of AAT in individuals predisposes them to elevated risk of early pulmonary emphysema and in some occasions hepatic damage. The PiZZ phenotype is the most frequently associated with low plasma concentrations of AAT.However much of this data comes from fully developed regions such as North America and Europe.
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