Abstract
Recent reports suggest that despite negative selection pressure, the deficient alpha-1-antitrypsin allele, PiZ, is maintained in a state of balanced polymorphism through the action of segregation distortion in heterozygous males. Published family data suggest that the same mechanism may be operating on behalf of the partially deficient allele PiS. Back-cross and intercross data, involving more than 250 informative meioses for PiS are reported here. Segregation analysis fails to confirm the hypothesis that the PiS allele is preferentially transmitted.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
