Aloe vera Mucilage as Solubility Enhancer in Tablet Formulation

Habibur Rahman

doi:10.4172/2155-9600.1000548

Abstract

Many of the health benefits associated with Aloe vera have been attributed to the polysaccharide contained in the gel of the leaves. On the other hand, the important pharmaceutical applications such as the use of the dried Aloe vera gel powder as an excipient in sustained release (SR) pharmaceutical dosage forms has to be explored further. The present study is development of water insoluble compound into a sustained release matrix tablets and the influence of Aloe vera gel powder in the dissolution and other physical properties of the SR matrix tablets were assessed. The HPMC and ethyl cellulose were used as polymer and different concentration of Aloe vera gel powder used as dissolution enhancer. Sustained release matrix tablets were formulated by direct compression method and subjected to various quality control studies as per the official pharmacopeial standards. The developed tablet formulation complies with the monograph. The results suggest that Aloe vera is improved the dissolution of curcumin. Dissolution kinetics suggests that all the formulation followed Korsemayer Peppas model via anomalous diffusion mechanism. To conclude the Aloe vera gel powder can be used as dissolution enhancer for improving the drug absorption of water insoluble drugs.

Highlights

The Aloe vera mucilage is well studied for its application in cosmetics
Piperine and Aloevera was used in the formulation as solubility enhancers, the present investigation is focus in a view to use the freeze dried polysaccharide fraction of Aloe vera mucilage in development of sustained release formulation for water insoluble compounds
Kinetic analysis of dissolution data: The rate and mechanism of release of curcumin from the sustain release matrix tablets were analyzed by fitting the dissolution data into the zero-order equation [10]: Q=k0t where Q is the amount of drug released at time t, and k0 is the release rate constant, fitted to the first order equation [11]: ln (100–Q)=ln 100–k1t (3) where k1 is the release rate constant

Summary

Introduction

The Aloe vera mucilage is well studied for its application in cosmetics. In the line the polysaccharide fraction present in the Aloe vera extract is finding new insights in the drug delivery technology. The proposed work is established the application of natural Aloe vera polysaccharide as an excipient in formulation research. Curcumin the phytoconstituent in turmeric was formulated as sustained release matrix tablets using HPMC.

Results

Conclusion