Abstract

Aloe genus plants, distributed in Old World, are widely known and have been used for centuries as topical and oral therapeutic agents due to their health, beauty, medicinal, and skin care properties. Among the well-investigated Aloe species are A. arborescens, A. barbadensis, A. ferox, and A. vera. Today, they account among the most economically important medicinal plants and are commonly used in primary health treatment, where they play a pivotal role in the treatment of various types of diseases via the modulation of biochemical and molecular pathways, besides being a rich source of valuable phytochemicals. In the present review, we summarized the recent advances in botany, phytochemical composition, ethnobotanical uses, food preservation, and the preclinical and clinical efficacy of Aloe plants. These data will be helpful to provide future directions for the industrial and medicinal use of Aloe plants.

Highlights

  • Aloe L. is the largest genus in the Xanthorrhoeaceae family, and geographically restricted to Old World [1]

  • We summarized the recent advances in botany, phytochemical composition, ethnobotanical uses, food preservation, and the preclinical and clinical efficacy of Aloe plants

  • Aloe plants have been reported for multiple biological properties, including antibacterial and antimicrobial, antitumor, anti-inflammatory, anti-arthritic, anti-rheumatoid, anticancer, and antidiabetic activities, detoxification, treating constipation, flushing out toxins and wastes from the body, promoting digestion, and reducing illnesses likelihood, as well as for immune system deficiencies [3,4,5,6,7,8,9]

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Summary

Introduction

Aloe L. is the largest genus in the Xanthorrhoeaceae family, and geographically restricted to Old World [1]. Aloe barbadensis, Aloe ferox, and Aloe vera are among the well-investigated Aloe species They account among the most economically important medicinal plants and are commonly used in primary health treatment, where they play a pivotal role in the treatment of various types of diseases, through biochemical and molecular pathway modulation [4]. The main commercial forms used in the food, cosmetics, and pharmaceutical industries [12,13] consisting of the plant’s fleshy leaves, gel, and latex are pills, jellies, creams, drinks, liquid, sprays, ointments, and lotions [3,13]. Gel, and latex are the base of the main commercial forms of aloe products (e.g., pills, jellies, creams, drinks, liquids, sprays, ointments, and lotions) [3,13]. In view of the ethnopharmacological uses and pharmacological properties of Aloe plants, this review narratively summarized the botany, phytochemical composition, ethnobotanical uses, food preservative effects, and preclinical and clinical efficacy of Aloe plants to provide further direction for its utilization in human welfare

Habitat and Cultivation of Aloe Plants
Phytochemical Composition of Aloe Plants
General Reports on Aloe Species Phytochemicals
Anthraquinones of Aloe Species
Anthrones of Aloe Species
Chromones of Aloe Species
Alkaloids of Aloe Species
Flavonoids of Aloe Species
Sterols of Aloe Species
Other Phenolic Constituent of Aloe Species
3.1.10. Non-Phenolic Components of Aloe Species
3.1.11. Vitamins of Aloe Species
3.1.12. Mineral Nutrients in Aloe species
Specific Reports on Aloe Phytoconstituents
Investigated Methods
Traditional Medicine Use of Aloe Plants
Food Preservative Applications of Aloe Plants
Antibacterial Activity
Antifungal Activity
Wound Healing and Cell Proliferation
Intestinal Absorption and Purgative Action
Anti-Inflammatory and Immunomodulatory Effects
Hepatoprotective Activity
Antioxidant Effect
Anthelmintic Activity
Anticancer Activity
7.10. Antidiabetic Activity
7.11. Antihyperlipidemic Activity
7.12. Effect on Estrogen Status
7.13. Antiulcer Activity
7.14. Treatment of Cardiovascular Disorders
7.15. Skin Use
7.16. Anti-Aging Effect
7.17. Antiallergic Activity
7.18. Effect on Central and Peripheral Nervous Systems
Clinical Efficacy of Aloe Plants in Humans
Antidiabetic Activity
Antihyperlipidemic Activity
Effect on Dental and Oral Diseases
Findings
Conclusions and Future Perspectives

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