Abstract
Holoprosencephaly (HPE) consists of a spectrum of malformations related to incomplete separation of the prosencephalon. It occurs between the 18th and the 28th day of gestation and affects both the forebrain and the face. It is estimated to occur in 1/16,000 live births and 1/250 conceptuses. Alobar HPE, the most common and most severe type of HPE, can be diagnosed in the first trimester of pregnancy using ultrasound. Among survivors, the long-term outcome is poor and depends on the type and severity of the pathology as well as associated anomalies. Keywords : Holoprosencephaly, Alobar, Malformation.
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