Abstract
Almotriptan is a selective serotonin receptor agonist used for the treatment of migraine headache. Its in vitro metabolic pathway in human liver subcellular fractions and in vivo metabolic pathway in rats, dogs, monkeys, and humans are shown. In humans, almotriptan was converted to the carbinolamine metabolite 2 via hydroxylation of the pyrrolidine group. This reaction was mainly catalyzed by CYP3A4 and 2D6. Metabolite 2 was further oxidized by aldehyde dehydrogenase to the open ring γ‐aminobutyric acid derivative 3 . N‐Demethylation at the dimethylamino group to form 4 was carried out by five different CYPs. FMO‐3 mediated N‐oxidation to form metabolite 5 , and MAO‐A catalyzed oxidative deamination to form indole acetic acid 6 and indole ethyl alcohol 7 . Metabolite 6 further formed a glucuronide conjugate.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
