Allylic Amination via Acid Catalyzed Leaving Group Activation

Abstract

Background: Allylic amination via acid catalyzed activation of a leaving group is promoted by non-expensive and low toxicity Lewis acid and Bronsted acid catalysts to give valuable allyl amine derivatives. In many cases, non-toxic byproducts such as water or acetic acid are generated. Moreover catalysts that perform the reactions in water as a solvent and the use of recyclable catalysts have been developed. Methods: Peer-reviewed research literature methods on allylic amination via acid catalyzed activation were compiled using data bases such as Sci-Finder and Scopus. Results: The mini-review summarizes the most important methods for allylic amination via acid catalyzed activation of a leaving group in the recent decade. These are divide in two main groups - Lewis acid and Bronsted acid catalysed reactions. Conclusion: Allylic amination via acid catalyzed activation of a leaving group meet criteria of the green chemistry paradigm which has motivated method development for this type of reaction in recent years. Keywords: Allylic substitution, allylic amination, lewis acids, bronsted acids, green chemistry, allylic alcohols, carbenium ion.