Abstract

Vitamin A deficiency (VAD) has killed millions of children in less-developed countries for at least the last three decades—roughly 2 million annually in the early 1990s alone (1⇓⇓–4). Although the number is declining, it was estimated to be 266,200 (4) at the start of the millennium. Widespread consumption of the genetically modified rice variety known as Golden Rice offers a potent and cost-effective strategy to combat vitamin A deficiency. Image credit: International Rice Research Institute; photo licensed under CC BY 2.0. The consumption of the genetically modified rice variety known as Golden Rice (GR) offers a potent and cost-effective strategy to combat VAD. But this innovation has been cast aside owing to fear or false accusations, resulting in numerous lives needlessly lost (1⇓–3). With the recent exception of the Philippines, governments have not approved the cultivation of GR (5). We believe it should be broadly approved and given the opportunity to save and improve lives. In high-income nations where populations have access to a diversity of foods, VAD is rare. In many low-income nations, however, populations have limited access to foods rich in vitamin A or beta-carotene, a vitamin A precursor; hence, VAD rates can be dangerously high in children. There have been recent improvements: from 1991 to 2013, the VAD rate among children in low- and middle-income countries declined from 39% to 29%, with notable improvements among children in East and Southeast Asia (4). However, children in sub-Saharan Africa and South and Southeast Asia continue to disproportionately experience VAD and its associated risks: infectious and diarrheal diseases, irreversible blindness and other sensory losses, and premature death (1, 4, 6). VAD has not been eradicated despite a variety of strategies used globally, including education on the value of dietary diversity, … [↵][1]2To whom correspondence may be addressed. Email: zilber11{at}berkeley.edu. [1]: #xref-corresp-1-1

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