Abstract
Inspired by bacterial chemosensory arrays, which are distinguished by high sensitivity and wide dynamic response range, we design a novel DNA-based metamaterial that self-assembles in presence of a ligand. Our design is based on flexible DNA-modules that undergo conformational restriction upon ligand binding. “Freezing” the internal degrees of freedom of a fraction of DNA-modules promotes formation of an extended array. We show that even in presence of exceedingly low concentrations of ligand, conformational restriction elicits an en masse, cooperative response of the material.
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