Abstract
Artificial allosterism: A ditopic ligand, which contains both bipyridine and tetra-aza-crown binding sites, coordinates one Cu(II) through all four N-donors of the tetradentate aza-crown unit. Reaction at the bipyridine site with another Cu(II) allosterically changes the aza-crown from being a tetradentate to a tridentate N-donor unit, a change in coordination mode that causes the successive binding of two Cu(II) ions to proceed with severe negative cooperativity (see scheme).
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