All-optical dual photoacoustic and optical coherence tomography intravascular probe

Sunish J Mathews,Callum Little,Christopher D Loder,Roby D Rakhit,Wenfeng Xia,Edward Z Zhang,Paul C Beard,Malcolm C Finlay,Adrien E Desjardins

doi:10.1016/j.pacs.2018.07.002

Abstract

Intravascular imaging in percutaneous coronary interventions can be an invaluable tool in the treatment of coronary artery disease. It is of significant interest to provide molecular imaging contrast that is complementary to structural contrast provided by optical coherence tomography (OCT) and intravascular ultrasound imaging (IVUS). In this study, we developed a dual-modality intravascular imaging probe comprising a commercial OCT catheter and a high sensitivity fiber optic ultrasound sensor, to provide both photoacoustic (PA) and OCT imaging. With PA imaging, the lateral resolution varied from 18 μm to 40 μm; the axial resolution was consistently in the vicinity of 45 μm. We demonstrated the clinical potential of the probe with 2-D circumferential PA and OCT imaging, and with multispectral PA imaging.

Highlights

Intravascular imaging in percutaneous coronary interventions can be an invaluable tool in the treatment of coronary artery disease
An all-optical IV imaging probe that provided both PA and optical coherence tomography (OCT), which included the use of an integrated MMF for PA excitation light delivery and a fiber optic heterodyne interferometer for ultrasound detection [19], was demonstrated
We report the development of a fiber-optic IV imaging probe that provides both OCT and PA imaging

Summary

Introduction

Intravascular imaging in percutaneous coronary interventions can be an invaluable tool in the treatment of coronary artery disease. Photoacoustic (PA) imaging, in which ultrasound (US) waves are generated in tissue using pulsed excitation light, can provide depth-resolved intravascular imaging with molecular contrast for lipids, at depths of up to 4 mm [4]. An all-optical IV imaging probe that provided both PA and OCT, which included the use of an integrated MMF for PA excitation light delivery and a fiber optic heterodyne interferometer for ultrasound detection [19], was demonstrated.

Results

Conclusion