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Abstract
Specific macrophage cytotoxin (SMC) is a soluble cytotoxin detected in the culture medium after a 2-hr interaction of alloimmune peritoneal macrophages and specific target cells at 37°C. The cytotoxicity of SMC affects only specific allogeneic cells and is not mediated through heat labile serum components. SMC is inactivated by heating at 56°C for 30 min and it is trypsin sensitive. The specificity and characteristics of SMC show it to be unique from other reported mouse in vitro cytotoxins.
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