Abstract
Abstract The kinetics of alloimmune hemolytic plaque-forming cells found in spleens of chickens after primary and secondary immunization was investigated. Rabbit anti-chicken immunoglobulin was employed for plaque development since chicken alloantibodies are non-hemolytic. Plaques formed by cells secreting IgM and IgG were developed separately by using rabbit antisera specific for each class of immunoglobulin. The kinetics as well as numbers of cells which produced antibodies specific for B blood group alloantigens during both the primary and secondary response were similar to what has been found for the mouse heteroimmune system. Certain advantages of the chicken alloimmune system for enumeration of hemolytic plaque-forming cells are discussed.
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