Abstract
Introduction : Allogro® is a demineralized freeze-dried bone allograft, a promising material for bone grafting, which is useful as a scaffold to fill bone defects and to restore bone loss in orthopedic and maxillofacial surgery.However, how Allogro® alters osteoblast activity to promote bone formation is poorly understood.Materials and Methods: To study how Allogro® can induce osteoblast differentiation in mesenchymal stem cells, the expression levels of bone related genes and mesenchymal stem cells marker were analyzed, using real time Reverse Transcription-Polymerase Chain Reaction.Results: Allogro® causes a significant induction of osteoblast transcriptional factor like osterix (RUNX2) and of the bone related genes osteopontin (SPP1), osteocalcin (BGLAP) and alkaline phosphatase (ALPL).Conclusion: The obtained results can be relevant to better understand the molecular mechanism of bone regeneration and as a model for comparing other materials with similar clinical effects.
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