Abstract
The responses of the solitary urochordate, Styela plicata , to first- and second-set tunic grafts confirm the existence of a sensitive histocompatibility system. Most first-set allografts were eliminated (median rejection time, RT 50, of 38.2 ± 5.9 days) whereas the majority of autografts remained viable. Allograft rejection exhibited significant memory with second-set allografts being lost far more rapidly ( RT 50 = 22.0 ± 2.6 days ) than first-set allografts. This alloimmune memory was shown to survive for up to 50 days after first-set rejection. Furthermore, 3rd party grafting indicated that memory was specific to the presensitizing tissue type. These results are discussed in terms of the evolution of vertebrate immunity.
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